The laboratory of Dr. Pereira studies the development, activation, and differentiation of B lymphocytes from the hematopoietic stem cell until the most terminally differentiated cell stage, the antibody-producing plasma cell. We use cellular, molecular, and biochemical approaches, combined with high resolution in vivo and in situ microscopy, to understand the localization and cellular cross-talk required for cellular differentiation to occur in vivo. The Pereira Lab is a member of the Department of Immunobiology, of the Yale Cancer Center and of the Yale Stem Cell Center.